Antirespiratory and Antiproliferative Activity of Anthralin in Cultured Human Keratinocytes
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چکیده
منابع مشابه
Serine-palmitoyl transferase activity in cultured human keratinocytes.
Sphingolipids comprise approximately 25% of the stratum corneum lipids and are considered critical constituents of the epidermal permeability barrier. Whether sphingoid base structures are synthesized in the epidermis or whether they are derived from circulating or dermal sources is not known. We report here the initial characterization of serine-palmitoyl transferase (EC 2.3.1.50; SPT), the ra...
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SIR, We were interested to read the recently published report' demonstrating a direct antiproliferative effect of cyclosporin A on cultured keratinocytes and fibroblasts. These authors observed a reversible, dose-dependent inhibitory effect and that the presence of serum attenuated this response. These findings were of interest to us because we previously observed the same phenomena and reporte...
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An increasing body of evidence has suggested trophic effects of peripheral nerves. In this study, the growth stimulatory properties of the sensory neuropeptides vasoactive intestinal polypeptide (VIP), substance P (SP), calcitonin generelated peptide (CGRP), and somatostatin (SOM) on cultured human keratinocytes were investigated. It was shown that VIP, in the presence of lethally treated 3T3 f...
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We used antibodies raised against individual desmosomal components to study calcium-induced desmosome formation in human keratinocytes. When keratinocytes are forced to grow as a monolayer by reducing the level of calcium ions in the culture medium, there is little contact between adjacent cells. Raising the level of calcium ions rapidly induces desmosome formation, and stratification occurs wi...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1985
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12275369